![]() This gamine persona belies a business savvy aided by her partnership with her creative director: twin sister (and accomplished violinist) Junia Lin Jónsdóttir. Fans have been showing up to concerts and secret sessions (like a recent London gig inside a boat’s floating bookstore) in “Laufey-core”-a preppy, retro look, complete with pleated miniskirts, penny loafers, and neat collars. ![]() Everyone wants to be represented.”Īnd represent they do. “If you go to my shows, a large portion of the audience is Asian and I don't think that's by accident. With contributing cultural factors like the K-Pop boom and the rise of contemporaries such as breakout Filipino-British singer and friend Beabadobee, it appears the possibilities are broadening for future generations. ![]() “I’ve become the artist I wanted to look up to,” Laufey says. “I didn't know I was allowed to do this or if people would accept me in this space,” says Gee. Neither Gee nor Laufey were exposed to popular Asian musicians when they were coming up. “Whether she’s plucking a cello or tinkling the ivories, she has a multidimensional and very visual appeal that extends beyond the tradition.” “The fact that she can stand in front of a mic with a Gibson ES-335 guitar wearing a gown is baller,” he says. “How many mainstream artists play the cello?” asks Derrick Gee, a Chinese-Australian radio host and music commentator who became aware of her when he ran 88Rising Radio, a platform for Asian artists on SiriusXM. There is something rather significant about what Laufey represents, both sonically and visually. ![]() Today, she’s drawn comparisons to everyone from torch songstress Julie London and The Queen of Jazz Ella Fitzgerald, to admirer Billie Eilish-who shared Laufey's acoustic cover version of Eilish's “ Happier Than Ever.” “The things that I was worried about are the reason I have my career today.” They also earned her the prestigious Presidential Scholarship to Berklee College Music, where she grew into her distinctive rich alto register (typically the second lowest for a female vocalist) and deep vibrato. And say everything’s going to be okay,” Laufey says. I've always had this deep voice and it just made me feel really old and different.” These hangups weren’t helped when one of the talent shows deemed her “the 14 year old girl with a voice of a 50 year old divorced woman.” “With that song, I wish I could go back to that version of myself and give her a hug. “I wanted to be a singer, but I didn't feel beautiful enough. I just remember feeling so incredibly out of place and different,” she says. “Pretty little blonde girls around me were having their first kisses and whispering together in gym class. “Letter To My Thirteen Year Old Self,” off her latest album, is a particularly poignant musical throwback to the Laufey she once was. “I'm still riding off of that foundation, stamina, and technique to this very day.” “I'm so thankful my mom pushed me to practice and instilled that kind of discipline,” she says. By age four she was playing piano, soon swapping the free-spirited Icelandic summers of endless daylight for cello band camp in Beijing. But today, she’s found her groove as Gen-Z’s resident emo-jazz romanticist.īorn in Reykjavik to Chinese mother who played violin in the local symphony and Icelandic economist father with a taste for Chet Baker, Laufey Lin Jónsdóttir and her identical twin sister were raised on an rich musical diet of big band standards, orchestral numbers, and classical string sonatas. “Everybody’s falling in love and I’m falling behind” she sings on her debut album, Everything I Know About Love. Over oat milk lattes in Los Angeles, Laufey (pronounced “lay-vay”) opened up on everything from her unconventional upbringing, to her fashion aspirations and relationship wins and woes, rife with all the plotlines that make for her signature lovelorn hooks. This week, she releases her sophomore album Bewitched. And the spell she casts is one spun from jazz-inspired, heartrending songs, that rack up millions of views with every coy TikTok missive. The ascending star of Icelandic music, singer, songwriter, and multi-instrumentalist Laufey is straight out of a twinkling Nordic fairytale.
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![]() ![]() ![]() a narrower-banded whitewall did start showing up in production sometime in the late spring of 1961. Tri power or 3X2 option became available in 62 and 63 know as the M series rated at 340 hp.ġ962 was the first year for pollution control on a Tbird.ĭay night mirrors were introduced but not standard in 1961.ġ961 was the last year for the wide white wall option on Tbird. Thunderbird there were about 43 Festival cars.ĪbThunderbird convertibles were used for JFK's inauguration in January of 1961.Ī principality of Monaco limited edition of 2000, was available in 1963.įour models were available in 62 and 63 Landau, and Sports Roadster added. The Indy pace car for 1961 was a convertible Two models were available in 61, convertible and Hard top, There was a vacuum resiovor for the brakes on some 61s, it sat on the opposite side of the battery same location and was connected by metal lines to the break booster. ![]() The 62 and 61 seats are the same, the 63 had a small badge on the front seats. The interior changed in mid 62, the dash is slightly wider and the door panels are smooth on top. The 61 AM radio plate did not have the word Thunderbird on it in 61 the 62 and 63 did. Options were power window, power drivers seat ( not certain about passenger) It amazes me when I run into the oddballs like these! Just thought you'd enjoy an interesting story! Troy"_ĪM Thunderbird radio was the only radio option in 1961, I believe 63 the AM/FM became available.īody side trim was an option for 62 only.įender skirts were option for all cars but the Sports Roadster, where they were not used. I ran into 2 '62 Birds with fixed columns! Naturally, I checked number plates and body stampings and found that both were indeed very early '62's. I've always known that the swing away steering was optional in '61 and standard from '62 on. _(there is a sideline to this from one of my readers " 2 "exceptions to the rule" I ran across while I was boneyard hunting in Michigan a couple of years ago. Swing away wheel was an option in 61 and became standard for 62 and 63. engine, which is similar to the 352 but not the same as also rated at 300 hp.Īll valve covers should say Thunderbird on them. Other Bits of Information regarding these carsĪll 61 to 63 used the 390 ci. while the other states may have used clear lenses with amber bulbs. According to research the amber lenses were installed in cars destined for Wisc. It seems that in 1963 these cars started using either amber bulbs or lenses for the front park / signal lights. In magazine reviews of the car, I noticed that the one featured had the PCV valve. From what I could find out, all cars destined for California had PCV valves, but it wasn't until late in the 1962 model run that all 1962 Tbirds had the PCV valve. I have a 1962 dated Feb 5 1962, and it still uses the older road draft crank case ventilation system. This is generally considered the first year for any kind of emission controls. I really enjoy your website! I just wanted to mention one thing about the 1962 Thunderbird's engine. Ģ7BF used an unusual top cover style hold down with one hole offset from center, because the squarebirds battery bracket required it. Measure the rear by the same method and th height should be 20.5". Measure at the highest point of the front wheel opening on each fender, height should be very near 27". Making sure you are on a level surface and the fuel level is topped off and your car has only it's original equipment on board such as jack and spare and not extra luggage etc., tires at proper pressure and size, rock it up and down by pushing on the front and rear bumpers. This is a simple method of measuring the ride height of your 61-63 Thunderbird. This is because 1963 was the first year that a clean air tube was used for the automatic choke from the exh. Power steering reservoir cover with and without air cond.ĭate for Dash and Door Panel change over wasĪir Cleaners for 1963 had a small hose nipple on the bottom whereas the 61-62 did not. The "M" series engines also had the following chromed itemsĪll throttle linkage to indlude cross piece and rod to firewall (trans kickdown brkt. Valve covers, "Thunderbird" stamped on them The Optional Chrome Dress-Up package included the following items:Īir cleaner (finned alum. If there is information you wish me to put here or if you find mistakes I should correct, please email me Here.īlock, heads, intake, front cover, oil pan, The following is an attempt to get some of the basic information regarding originality for Thunderbirds into the hands of all who want it and to do it for free. We proudly provide 24/7 emergency plumbing services in Atlanta! Atlanta Insulation Services Andrews online or call 77 for all your plumbing needs. We also offer emergency electrical services.Ĭontact R.S. We provide a full range of electrical services in Atlanta, including wiring, indoor & outdoor lighting, breaker panels, and generators. Whether you need a light fixture installed, a breaker box replaced, or want to upgrade your wiring, we can help! We can install, repair, and maintain practically any system in your home. Our certified Atlanta electricians have the technical knowledge and training to service the most advanced electrical systems. 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We can service your home’s gas furnaces, electric furnaces, boilers, or heat pumps. Our heating services in Atlanta include installation, repair, and maintenance. We can install, maintain, and repair systems manufactured by Lennox and many other leading manufacturers. ![]() Andrews, your comfort is our top priority! We provide 24/7 emergency service to keep your heating and cooling systems in exceptional condition. Andrews: Atlanta’s Leading HVAC, Plumbing & Electrical Contractor Serving Atlanta & the Surrounding Atlanta Metro Areas Atlanta HVAC Services: Installation, Repair & MaintenanceĪt R.S. Affected players can log into the relevant software and cash out their remaining balance using the ordinary withdrawal methods available to them, and they are welcome to do this at their convenience.” “We appreciate that many of our customers are passionate about using our services, and we regret the inconvenience that this will cause affected players. Following a recent review we have decided to stop offering real money games to players who are physically located in, or have a registered address in, a limited number of countries. “Our management team and advisors regularly review our operations market-by-market to assess commercial opportunities and business risks for our brands. Those countries - Italy, Estonia, Belgium, Denmark, and Spain - have an unchanged status in relation to the latest news.įlushDraw has received a statement from Eric Hollreiser, the Head of Corporate Communications for PokerStars, which confirms the pullout and reads as follows: The two Amaya Gaming sites, PokerStars in particular, also maintain a separate list of “ Restricted Jurisdictions” where play is accessible for that country’s firewalled players only through a state-licensed client. Previously, the only prohibited jurisdiction was the United States, along with that country’s territorial possessions. Occupied Palestinian Territory (Gaza Strip)Īll of the named countries are expected to be added in the near future to the list of “Prohibited Jurisdictions” published in the Terms of Service (TOS) of both the PokerStars and Full Tilt sites.Northern Cyprus (Turkish jurisdictional area).The lengthy list of countries includes a high percentage of Arab / Islamic states, where gambling is often banned by law.Īmaya has yet to release an official list of newly banned jurisdictions, but a consensus list culled from customer-support messages to affected players, plus independent postings on player forums, has resulted in the following list: Read moreĪmaya Gaming Withdraws PokerStars, Full Tilt Brands from Grey Markets 30th September 2014 // Industry, Legal News, NewsĬanada-based Amaya Gaming has announced the withdrawal of world online poker market leader PokerStars and secondary brand Full Tilt Gaming from approximately 30 so-called “grey market” jurisdictions, countries where online poker or online gambling is either unregulated by law or is explicitly banned in some form. The Triton Super High Roller Series scheduled for mid-Februry in Jeju, South Korea has become the first poker event impacted by concern over the expanded threat by the 2019 novel. ![]() 31st January 2020 Coronavirus Outbreak Forces Postponement of Triton Jeju Series.It seems like just yesterday that Larry David was arguing that it was too late to wish people Happy New Year and now. The year 2020 is already one-twelfth gone. ![]()
![]() Having said all that, I'm going to be putting my TR up for sale as I've ordered a new Full Carbon bike that will get me down in the 29/30 lb range. I don't think you would be making a bad decision either way, but the TR is more well rounded bike for everything. All Mountain, and you are doing a lot of lift service/bike park days, the AM would be a better option if you are more concerned with going downhill vs uphill. I think it's plenty capable on Enduro style trails, but if that is your main focus vs. Unfortunately, it won't be fast and all of your friends with lighter weight rigs will be waiting for you at the top of the hill. The 78.6 STA took me a little time to get used to but once you get comfortable with it you will appreciate how it helps put you in a great pedaling position to spin up the hills. ![]() It has crushed every downhill I have thrown at it but I ride MN trails and not CO/PNW trails. I have a medium 2021 TR Race with the Lyric up front and the Ultimate Coil out back. If you try to go a full size down you'll have a super cramped pedaling position because modern long reach bikes also have a corresponding steep seat tube. Thanks for the help.įWIW sizing down only works if you're in between sizes. The alternative would be the TR in a large frame, I just don't want the 140mm frame to limit me in the future. For context, I am 6ft but could still grow some. I have thought of sizing down on the AM and getting a medium rather than a large so I can control the bike a bit better but still hit bigger feautures, I still want to be comfortable though. I have heard the TR is decent on uphill, but can also handle DH situations. I want to be able to control the bike, especially in the air. I just don't want something like the AM to slow me down on uphill and technical sections of trail. So far I have hit a couple of pro lines with 20ft features on my current bike with 140mm recon upfront, so I'll definitely be going big. But, I am also starting Enduro/DH racing and love sketchy downhill. I have one year left of Highschool XC racing and will continue to ride mellower trails after school. Hey guys, I am about to upgrade my bike from a heavy trek fuel ex 5 that is too small for me to either the Commencal Meta TR 29 or Meta AM 29. ![]() ![]() (Courtesy of California Department of Corrections and Rehabilitation) A 2013 photo of Aswad Pops, 48 who died in San Quentin State Prison on Aug. The death of 48-year-old Aswad Pops is being investigated as a suicide, though the cause of death will not be determined until an autopsy is conducted, California Department of Corrections and Rehabilitation officials said in a statement. “Watching Nipsey inspired me to invest and own in our communities,” Emmy-nominated actress Issa Rae, also from Los Angeles, wrote on Twitter.A man sentenced to death in 2000 for taking part in the murder of four people, including a Corona man, at a Compton car wash died Thursday at San Quentin State Prison, officials said. Forbes magazine reported in February that with business partner Dave Gross, the rapper had purchased the Crenshaw plaza where his Marathon Clothing store is located, and had plans to knock it down and “rebuild it as a six-story residential building atop a commercial plaza where a revamped Marathon store will be the anchor tenant.” Outside of music, Hussle said he wanted to provide hope and motivation to those who grew up in Crenshaw like him, and pay it forward. Rapper Nas mourned Hussle’s death on Instagram and wrote, “It’s dangerous to be an MC. This (stuff has) got to stop man,” he said in the second video. Snoop Dogg posted a video of himself and Hussle together on Instagram, and posted a second clip sending prayers to the rapper’s family. NBA star Steph Curry tweeted, “God please cover and restore right now!!!” Many celebrities were mourning his death on social media. inspiring, humbling,” he said in an interview with the Recording Academy on the red carpet of the 2019 Grammys, which he attended with this daughter. “It’s my debut album so for my first one (to be nominated) out the gate, it’s like, it was overwhelming a little bit. Cardi B’s “Invasion of Privacy” won the honor. 4 on Billboard’s 200 albums charts and featured collaborations with Kendrick Lamar, Diddy, CeeLo Green and more.Īt this year’s Grammy Awards, “Victory Lap” was one of five nominees for best rap album in a year that hip-hop dominated the pop charts and streaming services and a number of top stars released projects, including Drake, Eminem and Kanye West. The proud West Coast rapper continued to build more hype for himself, scoring big when Jay-Z bought 100 copies of his 2013 mixtape “Crenshaw” for $100 each, and sent him a $10,000 check.ĭuring the 2016 presidential campaign, Hussle and rapper YG released the protest song “FDT,” short for "(Expletive) Donald Trump.” He later hit a new peak with “Victory Lap,” his critically acclaimed major-label debut album on Atlantic Records that made several best-of lists last year, from Billboard magazine to Complex. In 2010 he placed on hip-hop magazine XXL’s “Freshman Class of 2010" - a coveted list for up-and-coming hip-hop acts - alongside J. Hussle released a number of successful mixtapes that he sold out of the trunk of his car, helping him create a buzz and gain respect from rap purists and his peers. Music eventually happened for Hussle, who said in interviews that his stage name, a play on the 1960s and 70s rhyming standup comic Nipsey Russell, was given to him as a teen by an older friend because he was such a go-getter - always hustling. it’s like, we were just raised like if you with me and something goes now, I’m in it.” “So by being outside, being involved with hustling, being in the hood, doing things to try to get money, being young, you know riding your bike through the hood, getting shot at, your loved ones and homies that’s your age getting killed, getting shot at. ![]() “The culture of my area is the gang culture,” he explained in a 2014 interview with VladTV. Hussle said he got involved in street life as he tried to support himself, and he joined the gang Rollin 60’s Neighborhood Crips as a teenager. Hussle said his first passion was music but getting resources was tough after leaving his mother’s house at 14 to live with his grandmother. “And that’s cool, but there should be something that says, ‘Follow Elon Musk, follow (Mark) Zuckerberg.’” Hussle explained where he was coming from in a Los Angeles Times interview last year: “In our culture, there’s a narrative that says, ‘Follow the athletes, follow the entertainers,’” he said. ![]() ![]() ‘ The domain name can be applied for by the current registrant of…‘ ‘ The domain name is not currently reserved for priority allocation.‘ Your domain name is Contested if you see your domain and others in ‘Priority category 1 or 2’ (as per the example below.) We recommend you complete Step 4 – Contact Clickify and ask us to apply for your Contested domain(s) as this process can be quite complicated.Your domain name is not currently reserved for priority allocation – this means you can complete Step 3 – Register your Uncontested.Your domain name can be applied for by the current registrant – this means you need to complete Step 2 – Apply for a Priority Token to register the.au domain will fall into one of these 3 classifications: au domain name you are looking to register or your existing Australian extension domain e.g. ![]() To check if it’s available to register straight away use this tool –Įnter the. au domain registered or you have registered the only domain with another Australian extension, then the domain will be Uncontested and you can register the domain now. However, if you need help with this, please skip to the Need Help? section at the end of this page. The following is a step-by-step guide to walk you through the process. The team at Clickify is here to help make it easier and less confusing. au domain if other people have a similar domain in the au namespace. It may not be as simple as just registering the. If you don’t have an account you can register for a free account here: Register – Clickify Cloud. au domain extension.Ĭlickify clients can register via their Clickify Cloud account. If you are keen to further protect your business’s Australian identity online, help attract local search and protect your brand, we recommend applying for the. It is entirely your personal preference whether you choose to apply. Your existing domain names will continue to operate as normal, per auDA policy, regardless of whether you take up the option to register the matching. Please note, there is no obligation to register for a. The lodging fee to submit an application is $15.95 (including GST) and if uncontested the fee includes 12 months of registration. Otherwise, the Clickify team is happy to assist you and our Clickify Cloud customers with this application service. So you can contact your current registrar for your domain names for more information. au domain registrations and can assist with the priority application process. Most reputable domain name registrars are offering. If no applications are made by this date, it will become available for anyone in the general public to register at 8:00AM AEDT 4th October 2022. This is reserved for existing registrants who hold the matching keyword for an existing. There is a Priority Application Process period which runs until 9:59 AM AEST 21st September 2022. It’s possible there can be more than one registrant eligible for a. Registration Is Now Openįor brands with an Australian presence, the registration period to apply for their. Whether you are a small business or a corporation, your website is an important asset. If you already have, for example, and domains, you may like to consider for brand protection and to redirect any traffic from this domain to your main website. au Domain Administration ( auDA), released the new direct. On 24 March 2022, the governing body for. au direct domain registration is available for Australian businesses and what the process is to apply for them. We’ve prepared this update to help you understand exactly what is involved now that. au variation of their business domain names. ![]() au domain names with clients wanting to know how to apply to reserve the. The Clickify team has received many inquiries recently about the new direct. The Board revoked the license and the licensee no longer has the right to practice as an RN or to use the title.Ī Statement of Issues is a legal document, formally charging an applicant for initial licensure, with a violation(s) of the Nursing Practice Act, and notifying the public that a disciplinary action is pending against the applicant. If the licensee violates probation, the Board may lift the "stay" and revoke the license. However, the revocation is "stayed" or temporarily set aside, pending successful completion of probation. Revocation Stayed, Suspension, Probation: While on probation, the RN must be monitored by the Board for a set period of time. temporarily set aside) the revocation, and allowed the licensee to practice as an RN with a restricted license under terms and conditions of probation. The Board revoked an RN license, stayed (i.e. The Board issued a letter of reproval/reprimand for a minor violation the Nursing Practice Act, with no restrictions on the license. The Board members may vote to adopt or reject a Proposed Decision, or discuss it further before making a final decision. A proposed decision has to be adopted by the majority of the Board's members before it can go into effect. The Board is filing charges to revoke a licensee's probation for violating the terms and conditions of his or her probation.Īllows the licensee to practice as an RN under certain restrictions for a set period of time.Ī decision rendered by an Administrative Law Judge through an Administrative Hearing. Under California Penal Code Section 23, during a criminal proceeding, a judge may order that a licensee be suspended from practice as a registered nurse, or restricted in how he or she may practice registered nursing. Once licensed, the applicant is placed on probation, and must be monitored by the Board for a set period of time. The Board grants an initial license application. The Board denied an initial license application. Lack of knowledge or skill in discharging professional obligations as an RN.Ī license is suspended by an Administrative Law Judge due to the seriousness of the allegations in advance of the filing of an accusation and pending a final determination of the licensee's fitness to practice and provide nursing care. An extreme departure means the repeated failure to provide the required nursing care or failure to provide care or exercise precaution in a single situation which the nurse knew, or should have known, could result in patient harm. Indicates the date the disciplinary action goes into operation.Īn extreme departure from the standard of practice for RNs. Board members may vote to adopt or reject a default decision, or discuss it further before making a final decision. All charges are deemed true, and the default decision normally results in a revocation of the RN's license. ![]() This list is for illustration only and is not all-inclusive of the acts for which the Board may discipline an RN's license.Ī decision based on the RN's failure to provide a notice of defense after an accusation has been served, or failure to be present at an Administrative Hearing. Discipline TerminologyĪn Accusation is a legal document formally charging a registered nurse with a violation(s) of the Nursing Practice Act, and notifying the public that a disciplinary action is pending against that nurse.Ĭonvicted of a crime substantially related to the qualifications, functions, and duties of an RN:Ĭan apply to such crimes as embezzlement, child abuse, spousal abuse, battery, theft from a patient or client, or failure to report abuse. If the documents are not available for a discipline related matter, you may contact the Board's Enforcement Unit.Įmployers may subscribe to Nursys e-Notify in order to receive free automated license status updates for their employees. To view public documents relating to disciplinary actions taken by the Board, you may search by the individual's name or license number through the BreEZe License Verification system.
![]() During bidding, each player estimates the number of points they could score by melding and trick-taking. Generally, Pinochle comes in the three phases bidding, melding, and trick-taking. But custom rules can model the game to your habit. Our basic game presents the German rules. At the Pinochle Palace, you can play either variant. There are more differences between the German and American Pinochle traditions. Both come in a double deck with four suits that each present five ranks twice, resulting in 40 cards in total. Thus, traditional decks are either the Württembergian Pinochle pattern or the American pattern. Pinochle has strong roots in Germany and the USA. A game of four turns into Cross Pinochle, where two teams of two players oppose one another. But on top, there is also melding! At the Pinochle Palace, you can choose from the most popular modes: three-player Pinochle and four-player Pinochle. It involves classic bidding and trick-taking as usual. ![]() Pinochle is an interesting game of the trick-taking family. For a double deck with 6 or 8 players, Pinochle is played with a 96 card deck containing four sets of Aces through 9s for 6 players the dealer passes out 16 cards and for 8 players the dealer passes out 12 cards. If there are 3 players and pass cards is disabled, players get 16 cards if pass cards are enabled, players get 15 cards.įor a double deck with 4 players, Pinochle is played with an 80 card deck containing four sets of Aces through 10s the dealer passes out 20 cards. After teams are decided amongst the players, the dealer passes out 12 cards if there are 4 players, 8 cards if there are 6 players and 6 cards if there are 8 players. You May Like: Blueprint Free Above Ground Pool Deck Plans The Deck And The Dealįor a single deck, Pinochle is played with a 48 card deck containing two sets of Aces through 9s. Of course, any game from the Palace of Cards comes with English language settings in the game. Choose from Skat, Doppelkopf, and Sheepshead.ĭeplete your hand in shedding games, such as Canasta, Rummy, and Mau Mau, or apply patience and strategy in Spider and Klondike Solitaire. More Online Card GamesĪlongside Pinochle, we offer multiple popular and classic card games online: Be our guest and try another trick-taking game. Play with either three or four players in a match and choose between double deck and single-deck games. This allows for a more competitive scene.įurthermore, the online mode uses a matchmaking system that connects you to players with the same skill level. Either way, every match session has a variety of gameplay experiences. You get to choose whether you want to play against players online via Facebook or against the computer offline. Hence there are a total of 50 points available for tricks. Each Ace, Ten and King is worth one point, and the team who win the last trick get an extra 2 points. At the end of the play, each side counts the points they have taken in tricks. In each suit the cards rank, from highest to lowest, Ace, Ten, King, Queen, Jack. ![]() How to Play Double Deck Pinochle : Understand the Rules of Pinochle ![]() Lactic Acidosis and Severe Hepatomegaly With Steatosis:įatal cases have been reported with the use of nucleoside analogs, including lamivudine. ![]() Individuals of childbearing potential should be counseled on the consistent use of effective contraception Pregnancy testing is recommended before initiation of DOVATO.Assess the risks and benefits of DOVATO and discuss with the patient to determine if an alternative treatment should be considered at the time of conception through the first trimester of pregnancy due to the risk of neural tube defects.Monitoring for hepatotoxicity is recommended.In some cases, the elevations in transaminases were consistent with immune reconstitution syndrome or hepatitis B reactivation, particularly in the setting where anti-hepatitis therapy was withdrawn Patients with underlying hepatitis B or C or marked elevations in transaminases prior to treatment may be at increased risk for worsening or development of transaminase elevations with use of DOVATO.Hepatic adverse events have been reported, including cases of hepatic toxicity (elevated serum liver biochemistries, hepatitis, and acute liver failure), in patients receiving a dolutegravir-containing regimen without pre-existing hepatic disease or other identifiable risk factors.Clinical status, including liver aminotransferases, should be monitored and appropriate therapy initiated Discontinue DOVATO immediately if signs or symptoms of severe skin or hypersensitivity reactions develop, as a delay in stopping treatment may result in a life-threatening reaction.Hypersensitivity reactions have been reported with dolutegravir and were characterized by rash, constitutional findings, and sometimes organ dysfunction, including liver injury.Do not use DOVATO in patients receiving dofetilide.Do not use DOVATO in patients with previous hypersensitivity reaction to dolutegravir or lamivudine.Closely monitor hepatic function in these patients and, if appropriate, initiate anti-HBV treatment. Severe acute exacerbations of HBV have been reported in patients who are co-infected with HIV-1 and HBV and have discontinued lamivudine, a component of DOVATO. If DOVATO is used in patients co-infected with HIV-1 and HBV, additional treatment should be considered for appropriate treatment of chronic HBV otherwise, consider an alternative regimen. Emergence of lamivudine-resistant HBV variants associated with lamivudine-containing antiretroviral regimens has been reported. BOXED WARNING: PATIENTS CO-INFECTED WITH HEPATITIS B VIRUS (HBV) AND HIV-1: EMERGENCE OF LAMIVUDINE-RESISTANT HBV AND EXACERBATIONS OF HBVĪll patients with HIV-1 should be tested for the presence of HBV prior to or when initiating DOVATO. |
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